General Information

  • ID:  hor002509
  • Uniprot ID:  NA
  • Protein name:  Melittin
  • Gene name:  NA
  • Organism:  NA
  • Family:  NA
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  NA
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  GIGAVLKVLTTGLPALISWIKRKRQQ
  • Length:  26
  • Propeptide:  NA
  • Signal peptide:  NA
  • Modification:  T26 Glutamine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  melittin family
  • Mechanism:  NA
  • Cross BBB:  YES
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor002509_AF2.pdbhor002509_ESM.pdb

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Physical Information

Mass: 329361 Formula: C131H228N38O32
Absent amino acids: CDEFHMNY Common amino acids: L
pI: 12.55 Basic residues: 5
Polar residues: 6 Hydrophobic residues: 12
Hydrophobicity: 27.31 Boman Index: -1482
Half-Life: 30 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 135
Instability Index: 4473.08 Extinction Coefficient cystines: 5500
Absorbance 280nm: 220

Literature

  • PubMed ID:  7488630
  • Title:  Membrane Permeabilization by Alpha-Helical Peptides: A Flow Cytometry Study